Pharmaceutical grade MMC

Pharma-MMC, Pharmaceutical grade Mesoporous Magnesium Carbonate

Pharmaceutical grade Mesoporous Magnesium Carbonate, Pharma-MMC, is a proprietary drug delivery technology for amorphous stabilization and solubility enhancement of drug substances and for unique drug formulations. Pharma-MMC has a porous structure with a narrow pore size distribution and an extraordinary high surface area. The intrinsic pore properties of the material make it ideal as a carrier of active pharmaceutical ingredients. Its template-free synthesis provides for feasible manufacturing scale-up

Pore Size and Particle Size Matters

Pharma-MMC is a powder material consisting of pores up to 10 nm in size. These pores can be loaded with numerous pharmaceutical active ingredients and the confined space suppress crystallization and stabilizes the amorphous form of the drugs. At the same time, the powder material has a particle size distribution that is optimized for dissolution and to achieve a free-flowing powder that allows for large scale manufacturing of drug products.

Poorly Soluble Drugs

Drugs that are poorly soluble represent approximately 70% of all pharmaceutical drugs in development. Through delivery of the amorphous form of active ingredients an enhanced dissolution and hence increased bioavailability can be achieved. The Pharma-MMC drug delivery technology enables amorphous solid dispersions of numerous drugs, hence increasing the dissolution and the body’s ability to absorb the drug. This unique technology may be used to rescue particularly difficult drugs or to enable novel product formulations.

Industry Needs

Scalability is key to meet minimum industry requirements. Through focused development, we have successfully demonstrated that the MMC synthesis is scalable for grams to tons. The Pharma-MMC drug delivery technology addresses unmet industry needs:

• Template-free drug carrier
• Scalable Pharma-MMC manufacturing
• High drug-load
• Long term amorphous stability of poorly soluble drugs (>12 months)
• Novel product formulations
• Amorphous stabilization and Enhanced bioavailability
• Free-flowing powder