A next-generation bioavailability platform

Disruptive Pharma is an innovative clinical-stage pharmaceutical development company dedicated to transforming drugs with poor bioavailability into effective, patient-friendly oral solid dosage forms.

Our proprietary technology platform Formulite^® addresses key challenges in oral drug development:

• Optimized bioavailability: Through improved solubility and absorption
• Smaller pill size and reduced pill burden: Improved patient experience
• Cost-efficient manufacturing: Ideal for tableting and encapsulation
• Eco-friendly manufacturing process: Reduced solvent and polymer use

Dual business model

Our dual strategy supports the next phase of growth and commercialization, combining partnering-driven development with the advancement of selected product candidates.

• Partnering / Co-Development – tailored formulation and product development projects for external partners. This business area generates near-term revenues and long-term value through milestone-based development and licensing agreements.

• Product candidates – development of differentiated versions of established drugs, with the objective of entering partnerships at or before clinical proof-of-concept.

Improving drug products with Formulite

By leveraging our proprietary Formulite technology we can reformulate APIs to realize improved versions of selected products already on the market. The oral bioavailability of the API may be significantly enhanced by Formulite, resulting in a substantial API dose reduction with bioequivalent efficacy. This is expected to translate into lower inter-patient variability which also may improve API tolerability. Drugs based on APIs with poor water solubility typically exhibit high efficacy levels, but patients suffer from an unfavorable side effect profile, such as a high rate of gastro-intestinal complications.

Enabling new chemical entities

Formulation of novel drug compounds may be challenging. The Formulite technology offers several solutions for small molecule drug delivery needs. It does not matter if your drug compound exhibits poor water solubility or is difficult to formulate for other reasons. We can tailor make the best solution for your drug compound whether it is a new chemical entity (NCE) or an already known drug (API). A drug compound loaded into Formulite can be directly filled into capsules. This means that one uniform Formulite formulation can be used in all pre-clinical studies, through the clinical program, and finally the commercial product. Through Formulite your formulation challenges are mitigated, the technical development risk is reduced and development time due to reformulation is kept at a minimum.